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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK2
All Species:
13.64
Human Site:
S742
Identified Species:
27.27
UniProt:
Q9H0K1
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0K1
NP_056006.1
926
103915
S742
N
Q
M
Q
I
A
E
S
S
Y
P
Q
P
S
Q
Chimpanzee
Pan troglodytes
XP_508750
883
99166
S699
N
Q
M
Q
I
A
E
S
S
Y
P
Q
P
S
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546528
993
110460
S816
N
Q
M
Q
I
A
E
S
S
Y
P
P
G
Q
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFH6
931
104180
S742
N
Q
M
Q
I
A
E
S
S
Y
P
G
P
S
Q
Rat
Rattus norvegicus
Q9R1U5
776
84890
R612
N
K
I
K
G
L
A
R
Q
V
C
Q
S
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
S638
I
P
P
A
F
H
H
S
Q
Q
T
P
G
G
Y
Chicken
Gallus gallus
Q9IA88
798
88848
T635
F
Q
H
A
Q
P
N
T
C
I
Y
S
S
S
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
A974
L
D
S
A
P
P
Q
A
T
P
T
Q
H
Y
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
A1192
H
Q
L
G
V
G
M
A
V
P
M
S
P
M
Q
Honey Bee
Apis mellifera
XP_397175
718
80391
R555
H
L
D
L
V
H
L
R
P
P
S
T
P
P
E
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
K992
H
G
K
T
E
K
D
K
G
G
D
D
S
S
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
E349
Y
L
E
S
E
F
Q
E
T
T
D
S
G
S
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.2
N.A.
84.7
N.A.
90.8
43.2
N.A.
45.2
45.4
N.A.
31.5
N.A.
29.6
37.4
23.8
N.A.
Protein Similarity:
100
95.3
N.A.
87.5
N.A.
94.4
56.7
N.A.
58.6
58.9
N.A.
45.2
N.A.
40
49.3
38.1
N.A.
P-Site Identity:
100
100
N.A.
80
N.A.
93.3
20
N.A.
6.6
13.3
N.A.
6.6
N.A.
20
6.6
6.6
N.A.
P-Site Similarity:
100
100
N.A.
80
N.A.
93.3
40
N.A.
6.6
20
N.A.
26.6
N.A.
46.6
26.6
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
25
0
34
9
17
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% C
% Asp:
0
9
9
0
0
0
9
0
0
0
17
9
0
0
9
% D
% Glu:
0
0
9
0
17
0
34
9
0
0
0
0
0
0
9
% E
% Phe:
9
0
0
0
9
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
9
9
9
0
0
9
9
0
9
25
9
9
% G
% His:
25
0
9
0
0
17
9
0
0
0
0
0
9
0
9
% H
% Ile:
9
0
9
0
34
0
0
0
0
9
0
0
0
0
9
% I
% Lys:
0
9
9
9
0
9
0
9
0
0
0
0
0
0
0
% K
% Leu:
9
17
9
9
0
9
9
0
0
0
0
0
0
0
0
% L
% Met:
0
0
34
0
0
0
9
0
0
0
9
0
0
9
0
% M
% Asn:
42
0
0
0
0
0
9
0
0
0
0
0
0
0
9
% N
% Pro:
0
9
9
0
9
17
0
0
9
25
34
17
42
9
0
% P
% Gln:
0
50
0
34
9
0
17
0
17
9
0
34
0
9
42
% Q
% Arg:
0
0
0
0
0
0
0
17
0
0
0
0
0
0
0
% R
% Ser:
0
0
9
9
0
0
0
42
34
0
9
25
25
59
0
% S
% Thr:
0
0
0
9
0
0
0
9
17
9
17
9
0
0
0
% T
% Val:
0
0
0
0
17
0
0
0
9
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
34
9
0
0
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _